Description

Amgen Ire1α Inhibitor CAS NO 1630086-20-2 is a potent and selective small molecule inhibitor of the Inositol-requiring enzyme 1 alpha (IRE1α), a key mediator of the unfolded protein response (UPR) pathway. This compound is a critical research tool for investigating cellular stress responses, protein homeostasis, and their implications in diseases such as cancer, neurodegeneration, and diabetes. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on developing novel therapeutics targeting endoplasmic reticulum stress.

Application

• Biomedical Research: A key reagent for studying the molecular mechanisms of the Unfolded Protein Response (UPR) and endoplasmic reticulum (ER) stress signaling in vitro and in vivo.
• Oncology Research: Used to investigate the role of IRE1α in tumor cell survival, proliferation, and resistance to chemotherapy, supporting the discovery of new cancer treatment strategies.
• Neurodegenerative Disease Models: Applied in research models for Alzheimer's, Parkinson's, and other diseases to understand the link between ER stress and neuronal cell death.
• Metabolic Disorder Studies: Employed in diabetes and metabolic syndrome research to explore IRE1α's function in insulin resistance and pancreatic β-cell dysfunction.
• Inflammatory Pathway Analysis: Utilized to dissect the crosstalk between ER stress and inflammatory pathways, relevant for autoimmune and inflammatory disease research.
• Drug Discovery & Preclinical Development: Serves as a reference standard and a pharmacological tool for screening and validating new IRE1α-targeting drug candidates.

Basic Information

Product Name	Amgen Ire1α Inhibitor
CAS No.	1630086-20-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	IRE1α Inhibitor; IRE1α Kinase Inhibitor; AMG-18; Inositol-requiring enzyme 1α inhibitor; Endoplasmic Reticulum Stress Inhibitor; UPR Pathway Inhibitor; (3aR,4S,7R,7aS)-2-[(2S)-2-[[(2S)-2-(2-chloroacetamido)-3-phenylpropanoyl]amino]-3-phenylpropanoyl]-N-(1,3-thiazol-2-yl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1-carboxamide
EINECS	Contact for details

Quality Control

Our Amgen Ire1α Inhibitor is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is supported by comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.