Description

Pd-1/Pd-L1 Inhibitor 3 is a potent and selective small-molecule inhibitor designed to target the PD-1/PD-L1 immune checkpoint pathway. This compound matters for its potential to modulate the tumor microenvironment and enhance T-cell-mediated anti-tumor immunity, offering a promising avenue for cancer immunotherapy research. It is primarily needed by pharmaceutical R&D teams and academic researchers focused on developing novel oncology therapeutics and studying immune evasion mechanisms in various cancers.

Application

• Immuno-oncology Research: A key tool compound for in vitro and in vivo studies investigating the PD-1/PD-L1 signaling axis and its role in cancer immune evasion.
• Drug Discovery & Development: Serves as a lead compound or reference standard in high-throughput screening and structure-activity relationship (SAR) studies for novel immune checkpoint inhibitors.
• Preclinical Studies: Used to evaluate the efficacy of PD-1/PD-L1 blockade in combination with other therapies, such as chemotherapy, radiotherapy, or other immunomodulators.
• Biochemical Assays: Employed in binding affinity studies, cellular reporter assays, and other mechanistic studies to understand inhibitor potency and specificity.
• Academic Research: Facilitates fundamental research into T-cell biology, immune tolerance, and the tumor microenvironment across various cancer models.

Basic Information

Item	Details
Product Name	Pd-1/Pd-L1 Inhibitor 3
CAS No.	1629654-95-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PD-1/PD-L1 Inhibitor 3; BMS-8; BMS-8 (PD-1/PD-L1 inhibitor); (S)-1-((S)-2-(1H-Indol-3-yl)-1-(4-(5-methoxy-7-methyl-1H-indol-4-yl)piperazin-1-yl)ethyl)pyrrolidine-2-carboxamide; BMS-202; Nivolumab analogue small molecule inhibitor; PD-1/PD-L1 interaction inhibitor 3; Immune checkpoint small molecule inhibitor.
EINECS	Contact for details

Quality Control

Our Pd-1/Pd-L1 Inhibitor 3 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research use. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and potency. Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.