Description

Cdk8-In-1 CAS NO 1629633-48-2 is a potent and selective small-molecule inhibitor of the cyclin-dependent kinase 8 (CDK8) and its paralog CDK19. This compound matters as a critical research tool for investigating the Mediator complex's role in transcriptional regulation, cell cycle progression, and oncogenic signaling pathways. It is needed by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on oncology, inflammation, and metabolic disease research, providing a reliable chemical probe for target validation and mechanistic studies.

Application

• Biochemical Research: Used as a selective inhibitor to study the specific functions of CDK8 and CDK19 kinase activity in vitro.
• Oncology Research: A key tool for investigating the role of CDK8 in cancer cell proliferation, survival, and tumorigenesis, particularly in colorectal, breast, and hematological cancers.
• Transcriptional Regulation Studies: Employed to dissect the Mediator complex's mechanism in controlling gene expression and its response to various cellular signals.
• Drug Discovery & Target Validation: Serves as a reference compound and a starting point for the development of novel CDK8/19-targeted therapeutics.
• Signal Transduction Pathway Analysis: Utilized to map and understand downstream effects of CDK8 inhibition on pathways such as β-catenin, STAT1, and HIF1α.
• Inflammation and Immune Response Research: Applied to explore the connection between CDK8 activity and inflammatory cytokine production (e.g., IL-10) in immune cells.

Basic Information

Product Name	Cdk8-In-1
CAS No.	1629633-48-2
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.41 g/mol
Synonyms	CDK8-IN-1; Cdk8/19 Inhibitor; 4-[[4-[[(3S)-3-Methyl-4-morpholinyl]methyl]phenyl]amino]-5-(1H-pyrazol-5-yl)-2-pyrimidinamine; 5-(4-(((S)-3-Methylmorpholino)methyl)phenylamino)-1H-pyrazol-3-yl)pyrimidin-2-amine; Cdk8 Inhibitor; SEN-1; CDK8/19 inhibitor Cdk8-In-1
EINECS	Contact for details

Quality Control

Our Cdk8-In-1 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and assay results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert conditions for long-term stability. The product is light-sensitive (store away from light). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.