Description

K-Ras G12C-In-3 is a potent and selective small molecule inhibitor designed to target the oncogenic K-Ras G12C mutant protein. This compound is of significant interest in the field of targeted cancer therapy, offering a direct approach to inhibiting a historically "undruggable" target. It serves as a critical research tool and a potential lead compound for pharmaceutical R&D teams focused on developing novel oncology therapeutics, particularly for cancers driven by the K-Ras G12C mutation such as non-small cell lung cancer (NSCLC), colorectal cancer, and pancreatic ductal adenocarcinoma.

Application

• Biochemical Research: Used as a reference standard and active probe in in vitro assays to study K-Ras G12C signaling pathways, protein-protein interactions, and inhibition mechanisms.
• Drug Discovery & Development: Serves as a key pharmacological tool compound for hit-to-lead optimization, structure-activity relationship (SAR) studies, and preclinical proof-of-concept evaluations.
• Oncology Research: Employed in cell-based studies to assess the effects of K-Ras G12C inhibition on cell proliferation, apoptosis, and tumor growth in relevant cancer cell lines.
• High-Throughput Screening (HTS): Utilized as a control or validation compound in screening campaigns to identify new chemotypes or assess assay performance.
• Mechanistic Studies: Facilitates research into resistance mechanisms and combination therapy strategies for K-Ras G12C mutant cancers.

Basic Information

Product Name	K-Ras G12C-In-3
CAS No.	1629268-19-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	K-Ras G12C Inhibitor 3; KRAS G12C-IN-3; 1629268-19-4; K-Ras(G12C) inhibitor; G12C mutant KRAS inhibitor; Oncogenic Ras inhibitor; Potential names based on structure class (e.g., acrylamide-based covalent inhibitor)
EINECS	Contact for details

Quality Control

Our K-Ras G12C-In-3 is produced under strict quality management protocols to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical characterization, including purity assessment by HPLC and structural confirmation by NMR and mass spectrometry. A Certificate of Analysis (COA) detailing identity, purity, and analytical data is provided with every shipment to support your regulatory and documentation requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment to maintain stability and potency due to its hygroscopic and light-sensitive nature. Allow the vial to equilibrate to room temperature in a dry atmosphere before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	Contact for details
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.