Description

K-Ras G12C-In-2 is a potent and selective small molecule inhibitor designed to target the oncogenic KRAS G12C mutant protein. This compound is a critical research tool for investigating the role of mutated KRAS in cancer cell proliferation and survival, offering a direct path to validate therapeutic hypotheses. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on developing novel targeted cancer therapies, particularly in the fields of oncology and precision medicine.

Application

• Biochemical Research: Used as a reference standard and pharmacological tool in in vitro studies to characterize KRAS G12C inhibition.
• Drug Discovery & Development: Serves as a key intermediate or lead compound in the screening and optimization of novel KRAS-targeted oncology drugs.
• Mechanism of Action Studies: Enables detailed investigation into downstream signaling pathways (e.g., MAPK/ERK) affected by KRAS G12C inhibition.
• Preclinical Research: Utilized in cell-based assays and animal models to evaluate the efficacy and pharmacokinetics of potential anti-cancer agents.
• High-Throughput Screening (HTS): Acts as a control compound in assay development and validation for identifying new KRAS inhibitors.

Basic Information

Product Name	K-Ras G12C-In-2
CAS No.	1629267-75-9
Molecular Formula	C31H34F2N8O3
Molecular Weight	604.65 g/mol
Synonyms	KRAS G12C-IN-2; (S)-1-((S)-3-(4-Acryloylpiperazin-1-yl)-1-((1-(2,6-difluorophenyl)cyclopropyl)amino)-1-oxopropan-2-yl)-N-(4-fluorophenyl)pyrazole-4-carboxamide; ARS-1620 analog; KRASG12C inhibitor 2; G12C-IN-2; K-Ras G12C Inhibitor 2
EINECS	Contact for details

Quality Control

Our K-Ras G12C-In-2 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.