Description

K-Ras G12C-In-1 is a potent and selective small molecule inhibitor designed to target the oncogenic K-Ras G12C mutant protein. This compound is of significant value in the field of oncology research and drug discovery, offering a direct approach to studying and inhibiting a key driver mutation in various cancers. It is primarily needed by pharmaceutical R&D departments, biotechnology companies, and academic research institutions focused on developing novel targeted cancer therapies, particularly for non-small cell lung cancer (NSCLC), colorectal cancer, and pancreatic ductal adenocarcinoma.

Application

• Biochemical Research: Used as a critical tool compound for in vitro studies to investigate the signaling pathways, binding kinetics, and inhibition mechanisms of the K-Ras G12C mutant.
• Drug Discovery & Development: Serves as a lead compound or reference standard in high-throughput screening (HTS) campaigns and structure-activity relationship (SAR) studies for novel oncology therapeutics.
• Preclinical Studies: Employed in cell-based assays and animal models to evaluate the efficacy and pharmacokinetic properties of potential K-Ras G12C inhibitors.
• Mechanism of Action (MoA) Studies: Essential for understanding the covalent binding interaction with the cysteine residue at position 12 and the subsequent trapping of the protein in an inactive state.
• Combinatorial Therapy Research: Investigated in studies exploring synergistic effects when combined with other targeted agents or immunotherapies.

Basic Information

Product Name	K-Ras G12C-In-1
CAS No.	1629265-17-3
Molecular Formula	C30H31F2N7O3
Molecular Weight	575.61 g/mol
Synonyms	K-Ras G12C Inhibitor-1; KRAS G12C-IN-1; (S)-1-((S)-1-Acryloyl-4-(4-phenyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)piperidin-2-yl)-3-(4-(2-fluoro-6-(trifluoromethyl)phenyl)-2-methylpiperazin-1-yl)azetidin-2-one; 1629265-17-3; K-Ras(G12C) inhibitor 1; KRAS G12C inhibitor compound 1
EINECS	Contact for details

Quality Control

Our K-Ras G12C-In-1 is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by comprehensive analytical data, including HPLC, NMR, and MS. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request. We adhere to relevant quality management standards to support our global clientele in pharmaceutical and biotechnology research.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep at -20°C or below under desiccated conditions. The compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.