Description

Fezolinetant CAS NO 1629229-37-3 is a highly selective neurokinin 3 (NK3) receptor antagonist, representing a significant advancement in therapeutic research. This compound is crucial for its targeted mechanism of action, offering a novel approach to addressing specific physiological pathways. It is primarily required by pharmaceutical research and development organizations, contract research organizations (CROs), and academic institutions focused on developing treatments for conditions related to neurokinin signaling, such as menopausal vasomotor symptoms.

Application

• Pharmaceutical R&D for the development of non-hormonal therapies for menopausal hot flashes (vasomotor symptoms).
• Clinical Research Material as a reference standard or active pharmaceutical ingredient (API) in pre-clinical and clinical studies.
• Mechanistic Studies in neuroscience and endocrinology to investigate the role of the NK3 receptor pathway.
• Biochemical Assay Development for screening and profiling compounds targeting neurokinin receptors.
• Academic Research in university and institutional labs studying central nervous system disorders and hormone regulation.
• GMP Manufacturing for the production of drug substance under current Good Manufacturing Practices for regulatory submissions.

Basic Information

Product Name	Fezolinetant
CAS No.	1629229-37-3
Molecular Formula	C22H23FN4O2
Molecular Weight	394.45 g/mol
Synonyms	ESN364; Fezolinetant; 4-[(2S)-2-[4-(2-Fluorophenyl)piperazin-1-yl]propyl]-2H,4H-1,3-benzothiazin-2-one; ESN 364; 4-[(2S)-2-[4-(2-Fluorophenyl)-1-piperazinyl]propyl]-3,4-dihydro-2H-1,3-benzothiazin-2-one; (2S)-4-[2-[4-(2-Fluorophenyl)piperazin-1-yl]propyl]-3,4-dihydro-2H-1,3-benzothiazin-2-one
EINECS	Contact for details

Quality Control

Our Fezolinetant is manufactured under strict quality systems to ensure high purity and consistency for research and development purposes. Each batch undergoes comprehensive analytical testing, including HPLC for assay and purity, identification by spectroscopic methods (IR, NMR, MS), and control of specified impurities. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with the agreed specifications. We support development activities aligned with ICH guidelines for stability and impurity profiling.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Purity (HPLC)	≥99.0%
Single Unknown Impurity	≤0.5%
Total Impurities	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.