Description

1-Bromo-4-Chloro-3-Fluoro-2-Methylbenzene is a high-purity, multi-halogenated aromatic building block essential for advanced organic synthesis. Its unique substitution pattern makes it a critical intermediate for constructing complex molecules in pharmaceutical and agrochemical research. This compound is primarily sought by R&D chemists and process development scientists working on active pharmaceutical ingredients (APIs), crop protection agents, and specialty materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the fluorine and halogen motifs for enhanced bioactivity.
• Material Science Research: Serves as a precursor for liquid crystals, organic semiconductors, and advanced polymers where specific halogen atoms tune electronic properties.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions to create biaryl and complex aromatic systems.
• Chemical Library Development: Employed in parallel and combinatorial synthesis to generate diverse compound libraries for high-throughput screening.
• Fluorine Chemistry Studies: A valuable reagent for investigating the influence of fluorine atoms on molecular conformation, metabolic stability, and lipophilicity (LogP).

Basic Information

Product Name	1-Bromo-4-Chloro-3-Fluoro-2-Methylbenzene
CAS No.	1628524-91-3
Molecular Formula	C7H5BrClF
Molecular Weight	223.47 g/mol
Synonyms	2-Bromo-1-Chloro-4-Fluoro-3-Methylbenzene; 4-Chloro-3-fluoro-2-methyl-1-bromobenzene; 3-Fluoro-4-chloro-2-methylbromobenzene; 1-Bromo-4-chloro-3-fluoro-o-xylene; Benzene, 1-bromo-4-chloro-3-fluoro-2-methyl-; BCFMB (abbreviation)
EINECS	Contact for details

Quality Control

Every batch of 1-Bromo-4-Chloro-3-Fluoro-2-Methylbenzene is manufactured and tested under a strict quality management system. We guarantee high chemical purity and lot-to-lot consistency, supported by comprehensive analytical documentation. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to ensure compliance with your research and development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0% (Area %)
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.