Description

1-Bromo-2-Fluoro-3-Iodo-4-Methoxy-Benzene is a highly functionalized, multi-halogenated benzene derivative that serves as a versatile and valuable building block in advanced organic synthesis. Its unique combination of bromo, fluoro, and iodo substituents on a methoxy-benzene scaffold makes it an essential intermediate for constructing complex molecules with precise electronic and steric properties. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for applications in cross-coupling reactions, medicinal chemistry, and the development of liquid crystals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing halogen atoms to modulate bioactivity, metabolic stability, and lipophilicity.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides where the specific halogen pattern is critical for target interaction.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers, organic semiconductors, and liquid crystalline materials.
• Cross-Coupling Reactions: An excellent substrate for various metal-catalyzed reactions (e.g., Suzuki, Stille, Sonogashira) due to the differential reactivity of its bromo and iodo groups.
• Medicinal Chemistry & Drug Discovery: Employed in high-throughput screening libraries and structure-activity relationship (SAR) studies to explore novel chemical space.
• Chemical Biology Probes: Useful for synthesizing tagged molecules or probes for studying biological mechanisms and interactions.

Basic Information

Product Name	1-Bromo-2-Fluoro-3-Iodo-4-Methoxy-Benzene
CAS No.	1628450-73-6
Molecular Formula	C7H5BrFIO
Molecular Weight	330.92 g/mol
Synonyms	4-Methoxy-2-fluoro-1-bromo-3-iodobenzene; 2-Fluoro-3-iodo-4-methoxybromobenzene; 3-Iodo-2-fluoro-4-methoxybromobenzene; 1-Bromo-2-fluoro-3-iodo-4-methoxybenzene; Benzene, 1-bromo-2-fluoro-3-iodo-4-methoxy-; 2-Fluoro-3-iodoanisole, 1-bromo derivative
EINECS	Contact for details

Quality Control

Our 1-Bromo-2-Fluoro-3-Iodo-4-Methoxy-Benzene is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, meeting the exacting standards required for research and development. We employ advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry for comprehensive characterization. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and storage should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.