Description

Kdm5-In-1 is a potent and selective small molecule inhibitor targeting the KDM5/JARID1 family of histone demethylases. This compound is a critical research tool for investigating epigenetic regulation, cellular differentiation, and oncogenesis. It is primarily utilized by pharmaceutical R&D teams and academic researchers in the fields of oncology, epigenetics, and drug discovery.

Application

• Epigenetic Research: A key reagent for studying the role of histone H3K4 methylation dynamics in gene expression and chromatin remodeling.
• Oncology Studies: Used to investigate the function of KDM5 demethylases in cancer cell proliferation, stemness, and drug resistance mechanisms.
• Biochemical Assay Development: Serves as a reference standard and positive control in high-throughput screening (HTS) campaigns for novel epigenetic modulators.
• Cell Biology: Employed to probe cellular differentiation pathways and developmental biology where KDM5 activity is implicated.
• Preclinical Drug Discovery: Used as a lead compound or pharmacophore model for the design and optimization of new therapeutic agents targeting epigenetic enzymes.

Basic Information

Product Name	Kdm5-In-1
CAS No.	1628210-26-3
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.41 g/mol
Synonyms	KDM5-IN-1; KDM5 Inhibitor; JARID1 Inhibitor; (S)-2-(4-(4-(Dimethylamino)phenyl)-5-methylthiazol-2-yl)-1-(1H-indazol-5-yl)pyrrolidine-2-carboxamide; KDM5A/B/C/D Inhibitor; Histone Demethylase KDM5 Inhibitor; Epigenetic Inhibitor
EINECS	Contact for details

Quality Control

Our Kdm5-In-1 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment to ensure traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.