Description

Ret Kinase Inhibitor 1 CAS NO 1627856-64-7 is a potent and selective small molecule inhibitor targeting the Ret tyrosine kinase, a key signaling protein implicated in various cellular processes. This high-purity compound is essential for researchers and developers in the pharmaceutical and biotechnology sectors, providing a reliable tool for target validation and drug discovery programs. It is primarily utilized in preclinical research for investigating oncogenic pathways, screening compound libraries, and developing novel therapeutic agents for cancers and other diseases driven by Ret kinase activity.

Application

• Biomedical Research: A critical tool for in vitro and in vivo studies investigating the role of Ret kinase in cell proliferation, differentiation, and survival.
• Oncology Drug Discovery: Used in high-throughput screening (HTS) assays and lead optimization programs to develop novel anticancer therapeutics targeting RET-driven tumors (e.g., medullary thyroid cancer, non-small cell lung cancer).
• Signal Transduction Pathway Analysis: Enables the study of downstream signaling cascades (e.g., MAPK/ERK, PI3K/AKT) activated by Ret kinase to understand disease mechanisms.
• Chemical Biology & Proteomics: Serves as a selective probe for kinome-wide profiling and target engagement studies to assess specificity and off-target effects.
• Preclinical Development: Supports pharmacokinetic (PK), pharmacodynamic (PD), and efficacy studies in animal models for candidate drug evaluation.
• Academic & Institutional Research: Fundamental research reagent for universities and research institutes studying neurodevelopment, neuroendocrine tumors, and other RET-associated pathologies.

Basic Information

Product Name	Ret Kinase Inhibitor 1
CAS No.	1627856-64-7
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.42 g/mol
Synonyms	RET Inhibitor 1; 1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile, 6-[2-[[6-(4-fluorophenyl)-3-pyridazinyl]amino]ethyl]-; RPI-1; RET Kinase Inhibitor RPI-1; N-(4-(4-Methylpiperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxamide; ARQ-087 (developmental code); Ret Tyrosine Kinase Inhibitor; RET proto-oncogene inhibitor
EINECS	Contact for details

Quality Control

Our Ret Kinase Inhibitor 1 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with detailed specifications for all critical parameters. Our quality commitment aligns with standards expected for research-grade biochemicals, supporting reproducible and reliable scientific outcomes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.