Description

Pfi-2 CAS NO 1627676-59-8 is a potent and selective small-molecule inhibitor of P-TEFb (Positive Transcription Elongation Factor b), specifically targeting the CDK9 subunit. This compound matters for researchers as it provides a powerful tool to probe the mechanisms of transcriptional regulation, particularly in the context of HIV replication, cardiac hypertrophy, and various cancers. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on oncology, virology, and cardiovascular disease pathways.

Application

• Biochemical Research: A key tool compound for studying transcriptional elongation, RNA polymerase II activity, and P-TEFb-dependent gene expression pathways.
• Oncology Research: Investigation of CDK9 as a therapeutic target in various cancers, including leukemias and solid tumors, due to its role in regulating the expression of short-lived anti-apoptotic proteins.
• Virology Studies: Used to inhibit HIV-1 replication by blocking Tat-mediated transactivation, which is dependent on P-TEFb.
• Cardiovascular Research: Exploration of its effects in models of pathological cardiac hypertrophy and heart failure.
• Mechanistic Probe: Serves as a critical control in experiments to validate the specificity of CDK9 inhibition versus other kinases.
• Preclinical Development: Supports early-stage drug discovery programs aimed at developing novel CDK9 inhibitors for therapeutic applications.

Basic Information

Product Name	Pfi-2
CAS No.	1627676-59-8
Molecular Formula	C₂₀H₂₀N₆O
Molecular Weight	360.41 g/mol
Synonyms	Pfi 2; PFI-2; N-(4-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-2-methylphenyl)-5-methyl-1,2,4-oxadiazole-3-carboxamide; (S)-PFI-2; CDK9 Inhibitor PFI-2; P-TEFb Inhibitor PFI-2; PFI2; 1627676-59-8
EINECS	Contact for details

Quality Control

Our Pfi-2 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity confirmation and NMR for structural identity, to ensure compliance with high-purity research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and other critical parameters is provided with every shipment to guarantee reproducible and reliable performance in your experiments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.