Description

(S)-Pfi-2 (Hydrochloride) is a potent and selective small molecule inhibitor of cyclin-dependent kinase 2 (CDK2), a key regulator of the cell cycle. This compound is crucial for researchers investigating cell cycle dynamics, cancer biology, and developing targeted therapeutic strategies. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on oncology and cell signaling pathways.

Application

• Biochemical Research: A critical tool for studying CDK2 kinase activity, substrate specificity, and its role in cellular proliferation and DNA replication.
• Oncology Drug Discovery: Used as a reference standard and pharmacological probe in high-throughput screening (HTS) and lead optimization programs targeting CDK2 for cancer therapy.
• Cell Cycle Analysis: Employed in vitro to induce cell cycle arrest, typically at the G1/S phase, to study checkpoint mechanisms and apoptosis.
• Mechanistic Studies: Facilitates the investigation of CDK2's interaction with cyclins and other regulatory proteins within complex signaling networks.
• Preclinical Development: Serves as a key compound in proof-of-concept studies for evaluating the efficacy of CDK2 inhibition in disease models.

Basic Information

Product Name	(S)-Pfi-2 (Hydrochloride)
CAS No.	1627607-88-8
Molecular Formula	C₂₀H₂₅ClN₆O₂
Molecular Weight	416.90 g/mol
Synonyms	(S)-PFI-2 hydrochloride; PFI-2, (S)-Isomer, hydrochloride; 4-[[(2S)-2-[[6-(Cyclopropylmethoxy)-9H-purin-2-yl]amino]-3-hydroxybutanoyl]amino]benzenesulfonamide hydrochloride; CDK2 Inhibitor (S)-PFI-2 HCl; (S)-N-(4-Sulfamoylphenyl)-2-((6-(cyclopropylmethoxy)-9H-purin-2-yl)amino)-3-hydroxybutanamide hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-Pfi-2 (Hydrochloride) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. The product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.