Description

(3,3-Difluorocyclobutyl)Methanesulfonyl Chloride is a high-value, multi-functional chemical building block featuring a strained cyclobutyl ring and a reactive sulfonyl chloride group. This compound is essential for medicinal chemistry and advanced materials research, enabling the precise introduction of the (3,3-difluorocyclobutyl)methanesulfonyl moiety into target molecules. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers for the synthesis of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for constructing bioactive molecules, particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides with novel modes of action.
• Material Science: Serves as a precursor for creating specialized polymers and coatings with unique fluorinated properties.
• Chemical Biology: Employed as a probe or linker in proteomics and bioconjugation studies due to its reactive sulfonyl chloride handle.
• Custom Synthesis & Contract Manufacturing: A critical raw material for CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Product Name	(3,3-Difluorocyclobutyl)Methanesulfonyl Chloride
CAS No.	1622903-44-9
Molecular Formula	C6H9ClF2O2S
Molecular Weight	218.65 g/mol
Synonyms	(3,3-Difluorocyclobutyl)methanesulfonyl chloride; 1-(Chlorosulfonyl)methyl-3,3-difluorocyclobutane; Methanesulfonyl chloride, (3,3-difluorocyclobutyl)-; (3,3-Difluorocyclobutyl)methyl sulfonyl chloride; 1622903-44-9; (3,3-Difluorocyclobutyl)methanesulfonic acid chloride
EINECS	Contact for details

Quality Control

Our (3,3-Difluorocyclobutyl)Methanesulfonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, meeting the stringent requirements of pharmaceutical development. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality system is designed to support regulatory filings, and we can supply material compliant with ICH guidelines for impurities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.