Description

Gsk481 is a potent and selective small molecule inhibitor of the RIPK1 kinase, a key regulator of necroptosis and inflammation. This compound is of significant value for research into cell death pathways and inflammatory diseases. It is primarily utilized by pharmaceutical researchers and academic institutions focused on developing novel therapeutics for conditions like neurodegenerative disorders, inflammatory bowel disease, and ischemia-reperfusion injury.

Application

• Biomedical Research: A critical tool for studying the molecular mechanisms of necroptosis (programmed necrosis) and its role in various pathological states.
• Drug Discovery: Used as a reference compound or lead molecule in high-throughput screening and preclinical development of RIPK1-targeted therapies.
• Inflammatory Disease Models: Applied in in vitro and in vivo studies to investigate and validate RIPK1 as a therapeutic target for conditions such as ALS, multiple sclerosis, and sepsis.
• Cell Signaling Studies: Employed to dissect the TNF signaling pathway and the interplay between apoptosis, necroptosis, and inflammation.
• Academic & Institutional Research: Serves as a key reagent in university and research institute laboratories for fundamental biological research.

Basic Information

Product Name	Gsk481
CAS No.	1622849-58-4
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.41 g/mol
Synonyms	GSK481; GSK-481; 7-Oxo-2,4,7,8-tetrahydro-1H-cyclopenta[4,5]pyrrolo[2,3-b]pyridine-6-carbonitrile, 1,3,4,8-tetrahydro-2-[[4-(4-morpholinyl)phenyl]amino]-; RIPK1 Inhibitor GSK481; Receptor-Interacting Serine/Threonine-Protein Kinase 1 Inhibitor GSK481; 1,3,4,8-Tetrahydro-2-[[4-(4-morpholinyl)phenyl]amino]-7-oxo-2,4,7,8-tetrahydro-1H-cyclopenta[4,5]pyrrolo[2,3-b]pyridine-6-carbonitrile
EINECS	Contact for details

Quality Control

Our Gsk481 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a dry environment before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.