Description

2,5-Difluoropyridine-4-Boronic Acid, Pinacol Ester is a high-value, multi-functional boronic ester building block essential for modern synthetic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in pharmaceutical and advanced materials research. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex fluorinated heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly those containing fluorinated pyridine motifs to enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the difluoropyridine structure imparts specific biological activity.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile organoboron reagent for palladium-catalyzed coupling with various aryl/heteroaryl halides, enabling efficient library synthesis for drug discovery.
• Material Science Research: Employed in the creation of novel organic electronic materials, ligands for catalysis, and liquid crystals, where its boronic ester group allows for modular construction.
• Chemical Biology & Probe Development: Useful for creating fluorinated molecular probes and tags for studying biological systems and diagnostic applications.

Basic Information

Product Name	2,5-Difluoropyridine-4-Boronic Acid, Pinacol Ester
CAS No.	1622217-35-9
Molecular Formula	C11H12BF2NO2
Molecular Weight	239.03 g/mol
Synonyms	4,4,5,5-Tetramethyl-2-(2,5-difluoropyridin-4-yl)-1,3,2-dioxaborolane; 2-(2,5-Difluoropyridin-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (2,5-Difluoropyridin-4-yl)boronic acid pinacol ester; 2,5-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 2,5-Difluoropyridine-4-boronic acid pinacol ester; Pinacol 2,5-difluoropyridine-4-boronate; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,5-difluoropyridine
EINECS	Contact for details

Quality Control

Our 2,5-Difluoropyridine-4-Boronic Acid, Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency suitable for demanding synthetic applications. Comprehensive Certificates of Analysis (COA) with full analytical data are provided to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The container should be kept tightly sealed in a dry inert atmosphere to maintain stability, as boronic esters can be sensitive to prolonged exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.