Description

Methyl 2-Fluoro-5-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine-3-Carboxylate is a high-value, multi-functional boronic ester derivative designed for advanced synthetic chemistry. This compound serves as a critical building block in cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing fluorinated pyridine-based drug candidates, including kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, leveraging the fluoropyridine moiety for enhanced biological activity and metabolic stability.
• Material Science Research: Serves as a functional monomer or building block for creating advanced organic electronic materials, such as ligands for OLEDs or conductive polymers.
• Chemical Biology & Probe Development: Employed in the synthesis of labeled compounds and molecular probes for imaging and diagnostic applications due to its reactive boronate handle.
• Custom Synthesis & Contract Manufacturing: An essential reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.
• Academic Research: A valuable tool in university and institutional laboratories for methodological development in organoboron chemistry and medicinal chemistry projects.

Basic Information

Item	Details
Product Name	Methyl 2-Fluoro-5-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine-3-Carboxylate
CAS No.	1622217-20-2
Molecular Formula	C13H17BFNO4
Molecular Weight	281.09 g/mol
Synonyms	2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-carboxylic acid methyl ester; Methyl 2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinate; 2-Fluoro-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinic acid methyl ester; 5-Boronic acid, 2-fluoro-, 3-(methoxycarbonyl)pyridine, pinacol ester; Methyl 2-fluoro-5-(pinacolatoboron)nicotinate; 1622217-20-2; Pinacol 2-fluoro-5-(methoxycarbonyl)pyridine-3-boronate
EINECS	Contact for details

Quality Control

Our Methyl 2-Fluoro-5-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, assay, and impurity profiles to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) in a desiccator for long-term storage. Typical storage temperature is 2-8°C for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0% (by NMR)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.