Description

3,5-Difluoro-4-((2-(trifluoromethyl)pyridin-4-yl)oxy)benzaldehyde is a high-purity, multi-fluorinated aromatic aldehyde building block. This compound is of significant commercial interest for its role as a key intermediate in the synthesis of advanced active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific fluorine-containing motifs into complex molecules.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and other small-molecule therapeutic programs.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides where fluorinated pyridine and benzaldehyde structures confer enhanced bioactivity and stability.
• Material Science Research: Serves as a precursor for the development of advanced organic electronic materials, such as ligands for OLEDs or fluorinated polymers.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and tags for imaging and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity fluorinated intermediates.

Basic Information

Product Name	3,5-Difluoro-4-((2-(trifluoromethyl)pyridin-4-yl)oxy)benzaldehyde
CAS No.	1620579-54-5
Molecular Formula	C14H6F5NO2
Molecular Weight	315.20 g/mol
Synonyms	4-((2-(Trifluoromethyl)-4-pyridinyl)oxy)-3,5-difluorobenzaldehyde; 3,5-Difluoro-4-[2-(trifluoromethyl)pyridin-4-yl]oxybenzaldehyde; Benzaldehyde, 3,5-difluoro-4-((2-(trifluoromethyl)-4-pyridinyl)oxy)-; 1620579-54-5; 4-(2-(Trifluoromethyl)pyridin-4-yloxy)-3,5-difluorobenzaldehyde
EINECS	Contact for details

Quality Control

Our 3,5-Difluoro-4-((2-(trifluoromethyl)pyridin-4-yl)oxy)benzaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with cGMP and ISO standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.