Description

Autotaxin-In-1 is a potent and selective small-molecule inhibitor of the autotaxin (ATX) enzyme, a key regulator of lysophosphatidic acid (LPA) production. This compound matters for researchers and developers targeting the ATX-LPA signaling axis, which is implicated in fibrosis, inflammation, cancer progression, and neuropathic pain. It is needed by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on developing novel therapeutics for these challenging conditions.

Application

• Pharmaceutical Research & Development: A critical tool for in vitro and in vivo studies to validate autotaxin as a therapeutic target.
• Oncology Research: Investigation of tumor progression, metastasis, and the tumor microenvironment influenced by LPA signaling.
• Fibrosis Disease Models: Used in preclinical studies for pulmonary, hepatic, and renal fibrosis to assess anti-fibrotic efficacy.
• Inflammation and Immunology Studies: Exploration of the role of ATX/LPA in inflammatory pathways and immune cell recruitment.
• Neuropathic Pain Research: Evaluation of potential analgesics targeting the ATX-LPA axis in the nervous system.
• Biochemical Assay Development: Serves as a reference standard and positive control in high-throughput screening (HTS) and enzymatic assays.
• Mechanistic Biology: Tool compound for elucidating downstream signaling cascades and biological functions of autotaxin.

Basic Information

Product Name	Autotaxin-In-1
CAS No.	1619971-30-0
Molecular Formula	C₂₀H₂₀N₄O₃
Molecular Weight	364.40 g/mol
Synonyms	ATX Inhibitor 1; Autotaxin Inhibitor 1; 4-[[(4S)-4-(1,3-Benzothiazol-2-yl)-1,3-thiazol-2-yl]amino]-2-methoxybenzoic acid; BBT-1; (4S)-4-(1,3-Benzothiazol-2-yl)-N-(3-methoxy-4-carboxyphenyl)-1,3-thiazol-2-amine; PF-8380 analog; ENPP2 inhibitor
EINECS	Contact for details

Quality Control

Our Autotaxin-In-1 is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and MS, to ensure it meets the high standards required for research and development. Comprehensive Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. The product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.