Description

Gsk-3326595 is a potent and selective small molecule inhibitor targeting protein arginine methyltransferase 5 (PRMT5), a key enzyme involved in epigenetic regulation and cellular signaling. This compound is of significant interest for its role in advancing oncology and disease research by modulating gene expression and cell proliferation pathways. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies engaged in drug discovery and pre-clinical studies for cancer and other proliferative diseases.

Application

• Pharmaceutical Research & Development: Serves as a critical reference standard and active pharmaceutical ingredient (API) in the discovery and development of novel anti-cancer therapeutics.
• Biochemical Assays & Screening: Used as a potent tool compound in high-throughput screening (HTS) and in vitro assays to study PRMT5 inhibition and its downstream effects.
• Mechanism of Action (MoA) Studies: Essential for investigating the role of PRMT5 in epigenetics, signal transduction, and tumor biology to validate novel therapeutic targets.
• Pre-clinical Development: Employed in animal model studies to evaluate the pharmacokinetics, pharmacodynamics, and efficacy of PRMT5-targeted therapies.
• Academic & Institutional Research: A key reagent for fundamental research in cellular biology, epigenetics, and oncology within university and government laboratories.
• Process Chemistry & Scale-up: Used as an intermediate or final compound in the optimization of synthetic routes for GMP-scale manufacturing.

Basic Information

Product Name	Gsk-3326595
CAS No.	1616392-22-3
Molecular Formula	C₂₀H₂₅N₅O₃
Molecular Weight	383.45 g/mol
Synonyms	PF-06939999; EPZ015666 (Analog/related); PRMT5 Inhibitor; (S)-N-((S)-1-Cyano-2-(4'-fluoro-[1,1'-biphenyl]-4-yl)ethyl)-1-(2-(dimethylamino)ethyl)-5-oxopyrrolidine-2-carboxamide; 2-Pyrrolidinecarboxamide, N-[(1S)-1-cyano-2-(4'-fluoro[1,1'-biphenyl]-4-yl)ethyl]-1-[2-(dimethylamino)ethyl]-5-oxo-, (2S)-
EINECS	Contact for details

Quality Control

Our Gsk-3326595 is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency suitable for research and development. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. Certificates of Analysis (COA) with detailed specifications are provided and can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.