Description

Seco-Duocarmycin Ma is a potent synthetic derivative of the duocarmycin class of antitumor antibiotics, known for its sequence-selective DNA alkylation properties. This compound is a critical advanced intermediate and research tool for the development of novel antibody-drug conjugates (ADCs) and targeted cancer therapeutics. It is primarily utilized by pharmaceutical R&D departments, biotechnology firms, and academic research institutions focused on oncology drug discovery and preclinical studies.

Application

• Antibody-Drug Conjugate (ADC) Payload: Serves as a highly potent warhead for the synthesis of next-generation ADCs targeting specific cancer cell antigens.
• Oncology Research: Used as a reference standard and active pharmaceutical ingredient (API) intermediate in preclinical studies of novel chemotherapeutic agents.
• Mechanistic Studies: Employed in biochemical research to investigate DNA minor groove binding and alkylation mechanisms.
• Structure-Activity Relationship (SAR) Analysis: A key compound for medicinal chemists to design and evaluate analogs with optimized potency and selectivity.
• Bioconjugation Chemistry: Provides a reactive scaffold for linking to monoclonal antibodies, peptides, or other targeting ligands.

Basic Information

Product Name	Seco-Duocarmycin Ma
CAS No.	1613286-57-9
Molecular Formula	C31H38N4O7
Molecular Weight	578.66 g/mol
Synonyms	Seco-Duocarmycin MA; (1S,8S,20S)-20-[(Cyclopropa[c]pyrrolo[3,2-e]indol-4(5H)-yl)carbonyl]-1,8-dihydroxy-12-methoxy-2,7,10,16-tetramethyl-4,13-dioxo-3,17-diazapentacyclo[11.7.0.0²,¹⁰.0⁵,⁹.0¹⁵,¹⁹]icosa-5,9,11,18-tetraene-19-carboxylic Acid; Duocarmycin SA Analogue; CC-1065 Analogue; DNA Alkylating Agent
EINECS	Contact for details

Quality Control

Our Seco-Duocarmycin Ma is manufactured under strict quality systems suitable for research and development applications. Each batch is characterized and tested to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing results from HPLC, NMR, and MS analysis is provided with every shipment to support your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. For short-term storage (up to one month), the material may be kept at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.