Description

3-Bromo-4-Chloro-5-Fluoropyridine Hydrochloride is a high-purity, multi-halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in providing a versatile and reactive scaffold for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for research chemists and process development scientists working on novel active ingredients, including kinase inhibitors and other small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for targeted cancer therapies and kinase inhibitors.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging its halogenated pyridine core.
• Chemical Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to introduce complex halogenated pyridine motifs into larger molecular architectures.
• Material Science: Serves as a monomer or functionalization agent in the creation of specialty polymers and advanced organic electronic materials.
• Contract Research & Development (CRO/CMO): Supplied to research organizations for custom synthesis projects and library generation for high-throughput screening.

Basic Information

Product Name	3-Bromo-4-Chloro-5-Fluoropyridine Hydrochloride
CAS No.	1613192-96-3
Molecular Formula	C5H3BrClFN•HCl
Molecular Weight	267.35 g/mol (Free base)
Synonyms	3-Bromo-4-chloro-5-fluoropyridine HCl; 5-Fluoro-3-bromo-4-chloropyridine hydrochloride; 4-Chloro-3-bromo-5-fluoropyridine hydrochloride; Pyridine, 3-bromo-4-chloro-5-fluoro-, hydrochloride (1:1); 1613192-96-3; 3-Br-4-Cl-5-F-Pyridine•HCl
EINECS	Contact for details

Quality Control

Our 3-Bromo-4-Chloro-5-Fluoropyridine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and relevant industry standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area%)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.