Description

Ortataxel is a potent semi-synthetic taxane derivative, a next-generation microtubule-stabilizing agent. Its primary value lies in its potential to overcome multidrug resistance in oncology, offering a promising pathway for advanced cancer therapeutics. This compound is essential for pharmaceutical R&D teams, academic researchers, and manufacturers focused on developing novel chemotherapeutic agents and targeted drug delivery systems.

Application

• Oncology Research & Drug Development: A key intermediate or active pharmaceutical ingredient (API) in the synthesis of novel anti-cancer drugs targeting resistant tumors.
• Mechanistic Studies: Used in biochemical and pharmacological research to study microtubule dynamics, cell cycle arrest, and apoptosis induction.
• Formulation Development: Serves as a critical component in the development of liposomal, nanoparticle, or conjugate-based drug delivery systems to improve solubility and bioavailability.
• Preclinical & Clinical Trials: Supplied as a high-purity reference standard or bulk material for preclinical animal studies and clinical trial material (CTM) manufacturing.
• Combinatorial Therapy Research: Investigated in combination with other chemotherapeutic agents or modalities to enhance therapeutic efficacy and overcome resistance mechanisms.

Basic Information

Product Name	Ortataxel
CAS No.	1613081-64-3
Molecular Formula	C45H53NO14
Molecular Weight	831.91 g/mol
Synonyms	Ortataxel; (3'R,4S,4'S,5R,6S)-6-[(1,1-Dimethylethoxy)carbonyl]-4-(acetyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,13,14,14a-tetradecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl benzoate; BAY59-8862; IDN-5109; SB-T-101131; Taxane derivative BAY 59-8862
EINECS	Contact for details

Quality Control

Our Ortataxel is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and stringent control of residual solvents and impurities to meet research and pharmaceutical-grade standards. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring full traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. Keep the container in a dry, cool, and well-ventilated area. For long-term storage, consider storing under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.