Description

Mps1-In-3 is a potent and selective small-molecule inhibitor of the monopolar spindle 1 (Mps1/TTK) kinase, a key regulator of the spindle assembly checkpoint. This compound is a critical research tool for investigating cell cycle dynamics, mitotic fidelity, and the role of Mps1 in oncogenesis. It is primarily utilized by researchers and scientists in the fields of academic research, pharmaceutical R&D, and biotechnology for target validation and preclinical studies.

Application

• Biochemical Research: Used as a selective inhibitor to study the enzymatic activity and structure-activity relationships of the Mps1 kinase in vitro.
• Cell Biology Studies: Essential for probing the spindle assembly checkpoint function, chromosome segregation, and mitotic progression in various cell lines.
• Cancer Research: Investigated for its potential to induce aneuploidy and cell death in cancer models, aiding in the exploration of novel oncology therapeutic targets.
• High-Throughput Screening (HTS): Serves as a reference compound or positive control in screening campaigns to identify new Mps1 modulators.
• Mechanistic Studies: Employed to dissect signaling pathways and protein-protein interactions dependent on Mps1 kinase activity.
• Preclinical Development: Supports early-stage drug discovery programs focused on developing anti-mitotic cancer therapies.

Basic Information

Product Name	Mps1-In-3
CAS No.	1609584-72-6
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.42 g/mol
Synonyms	Mps1 Inhibitor 3; TTK Inhibitor 3; MPS1-IN-3; 2-[[4-[(4-Methylpiperazin-1-yl)methyl]phenyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide; N-(2-Aminophenyl)-4-[[(4-pyridin-3-ylpyrimidin-2-yl)amino]methyl]benzamide (common mis-association, verified for accuracy); Mps1/TTK Kinase Inhibitor
EINECS	Contact for details

Quality Control

Our Mps1-In-3 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and structural identity. A comprehensive Certificate of Analysis (COA) detailing purity, potency, and impurity profiles is provided with every shipment to support your research reproducibility and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and potency. Allow the vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.