Description

Amg319 is a potent and selective small molecule inhibitor of the PI3Kδ (Phosphoinositide 3-kinase delta) isoform. This compound is a critical research tool for investigating B-cell receptor signaling and its role in hematological malignancies and inflammatory diseases. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in oncology and immunology drug discovery. The high specificity of Amg319 makes it an essential reference standard for validating novel therapeutic targets and screening related compounds.

Application

• Biochemical Research: Used as a selective probe to study the specific biological functions and signaling pathways of PI3Kδ in cellular models.
• Drug Discovery & Development: Serves as a key reference compound and positive control in high-throughput screening (HTS) campaigns for identifying new PI3Kδ inhibitors.
• Oncology Research: Investigated in preclinical studies for its potential therapeutic effects against B-cell cancers such as chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma.
• Immunology & Inflammation Studies: Applied in research models to understand and modulate immune cell activation, relevant to conditions like rheumatoid arthritis and asthma.
• Mechanism of Action (MoA) Studies: Employed to elucidate the downstream effects of PI3Kδ inhibition and to validate target engagement in complex biological systems.
• Pharmacology & Toxicology Profiling: Used in ADME (Absorption, Distribution, Metabolism, Excretion) and safety assessment studies for related drug candidates.

Basic Information

Product Name	Amg319
CAS No.	1608125-21-8
Molecular Formula	C₂₃H₂₅N₅O₂
Molecular Weight	403.48 g/mol
Synonyms	AMG-319; AMG 319; 2-((2S)-1-(7H-Purin-6-ylamino)propan-2-yl)-5-fluoro-3-phenylquinazolin-4(3H)-one; PI3Kδ Inhibitor AMG319; (2S)-2-[(6-Aminopurin-9-yl)amino]-1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propan-1-one; Selective PI3K Delta Inhibitor AMG-319
EINECS	Contact for details

Quality Control

Our Amg319 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) documenting identity, purity, and strength is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. Allow the product to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake. Keep the container in a well-ventilated, secure area designated for research chemicals.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.