Description

Cdk7-In-1 CAS NO 1604810-84-5 is a potent and selective small molecule inhibitor of cyclin-dependent kinase 7 (CDK7), a key regulator of the cell cycle and transcription. This compound is a critical research tool for investigating CDK7's role in oncology, transcriptional regulation, and cellular proliferation pathways. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on developing novel cancer therapeutics and exploring fundamental cell biology mechanisms.

Application

• Biochemical Research: Used as a selective probe to study CDK7 kinase function and its interaction with other cell cycle components in in vitro assays.
• Oncology Drug Discovery: Serves as a lead compound or reference standard in high-throughput screening campaigns and structure-activity relationship (SAR) studies for novel anticancer agents.
• Transcriptional Regulation Studies: Enables investigation into the role of CDK7 in controlling RNA polymerase II-mediated transcription and gene expression.
• Cell Cycle Analysis: Applied in cellular models to dissect the specific effects of CDK7 inhibition on cell cycle progression and checkpoint control.
• Preclinical Development: Utilized in pharmacokinetic, pharmacodynamic, and efficacy studies in relevant animal models of cancer.

Basic Information

Product Name	Cdk7-In-1
CAS No.	1604810-84-5
Molecular Formula	C₂₀H₂₀N₆O₂S
Molecular Weight	408.48 g/mol
Synonyms	CDK7-IN-1; Cdk7 Inhibitor 1; 5-((4-((4-Methylpiperazin-1-yl)methyl)phenyl)amino)pyrazolo[1,5-a]pyrimidine-3-carboxamide; THZ1 derivative; CDK7/12/13 Inhibitor; Cyclin-dependent kinase 7 inhibitor; Research Compound 1604810-84-5
EINECS	Contact for details

Quality Control

Our Cdk7-In-1 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert conditions for long-term stability. The material is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.