Description

Dxd CAS NO 1599440-33-1 is a high-purity, advanced pharmaceutical intermediate and linker compound of significant importance in modern bioconjugation and antibody-drug conjugate (ADC) development. Its core value proposition lies in enabling the precise and stable attachment of potent cytotoxic payloads to targeting antibodies, a critical step in creating next-generation targeted cancer therapies. This compound is essential for research institutions, biotechnology firms, and pharmaceutical companies engaged in the synthesis and optimization of novel ADC candidates and other targeted biopharmaceuticals.

Application

• Antibody-Drug Conjugate (ADC) Payload Linkage: Serves as a critical cleavable linker for attaching cytotoxic drugs (e.g., exatecan derivatives) to monoclonal antibodies.
• Bioconjugation Chemistry: Used in the site-specific conjugation of small molecule therapeutics to proteins, peptides, and other biological macromolecules.
• Precision Oncology Research: A key building block in the development of targeted cancer therapies that aim to improve efficacy and reduce systemic toxicity.
• Pharmaceutical Intermediate Synthesis: Employed in the multi-step synthesis of complex active pharmaceutical ingredients (APIs) for oncology.
• Process Development & Scale-up: Supports chemical process research and development (R&D) and manufacturing scale-up for clinical and commercial ADC production.

Basic Information

Product Name	Dxd
CAS No.	1599440-33-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Deruxtecan linker component; DXd; ADC linker payload; (3S,5R)-1-((S)-2-((2,5-dioxopyrrolidin-1-yl)oxy)-2-oxo-1-(2-oxo-2-((((3S,5R)-1-(2-((2-(2,5-dioxo-2H-pyrrol-1(5H)-yl)ethoxy)carbonyloxy)ethyl)-5-methyl-2-oxopiperidin-3-yl)carbamoyl)oxy)ethylamino)ethyl)-5-methyl-2-oxopiperidine-3-carboxylic acid; Exatecan derivative linker; Topoisomerase I inhibitor linker.
EINECS	Contact for details

Quality Control

Our Dxd is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, critical for sensitive bioconjugation applications. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Single Unknown Impurity	≤ 0.5%
Total Impurities	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.