Description

Ibrutinib-Biotin CAS NO 1599432-18-4 is a high-purity biochemical conjugate designed for advanced proteomics and drug discovery research. This compound is a critical tool for studying the Bruton's tyrosine kinase (BTK) signaling pathway through affinity-based techniques. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and CROs specializing in oncology and immunology. The product enables precise target identification and validation studies.

Application

• Biochemical Research: Used as a probe for affinity purification and pull-down assays to isolate and study BTK and its interacting protein complexes.
• Proteomics Studies: Facilitates the identification and quantification of BTK-binding partners in complex biological samples via mass spectrometry.
• Drug Discovery Platforms: Serves as a key reagent in high-throughput screening (HTS) assays to discover and characterize novel BTK inhibitors.
• Diagnostic Development: Employed in the development of diagnostic kits and assays for monitoring BTK activity and expression levels.
• Chemical Biology: Acts as a versatile molecular tool for studying kinase function, signal transduction pathways, and cellular mechanisms in cancer research.
• Bioconjugation & Labeling: Provides a biotinylated handle for streptavidin-based detection, imaging, and diagnostic applications.

Basic Information

Product Name	Ibrutinib-Biotin
CAS No.	1599432-18-4
Molecular Formula	C40H48N8O6S
Molecular Weight	768.93 g/mol
Synonyms	Ibrutinib Biotin Conjugate; (R)-1-((3R)-3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one Biotin Conjugate; BTK Inhibitor Biotin Conjugate; PCI-32765-Biotin; Avila-32765-Biotin; Ibrutinyl-Biotin; Biotinylated Ibrutinib; BTK Probe-Biotin
EINECS	Contact for details

Quality Control

Our Ibrutinib-Biotin is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment. For long-term storage, keep the container sealed under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.