Description

Brd2 CAS NO 1597439-91-2 is a potent and selective small-molecule inhibitor of the Bromodomain-containing protein 2 (BRD2), a key epigenetic reader protein involved in transcriptional regulation. This compound is a critical research tool for investigating the role of BRD2 in cellular processes, disease pathways, and for validating novel therapeutic targets. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on oncology, inflammation, and epigenetic drug discovery.

Application

• Epigenetics Research: Used as a selective chemical probe to study BRD2 function and bromodomain biology in vitro and in vivo.
• Drug Discovery & Target Validation: Serves as a lead compound or reference standard in high-throughput screening and hit-to-lead optimization campaigns for BRD2 inhibitors.
• Oncology Research: Investigated for its effects on cancer cell proliferation, apoptosis, and tumor growth in preclinical models, particularly in cancers driven by transcriptional dysregulation.
• Inflammatory Disease Studies: Applied in research exploring the role of BRD2 in modulating immune responses and inflammatory signaling pathways.
• Biochemical Assay Development: Employed as a standard inhibitor in developing and calibrating biochemical assays (e.g., TR-FRET, AlphaScreen) for bromodomain activity.
• Mechanistic Studies: Facilitates the understanding of gene expression mechanisms and the functional consequences of bromodomain inhibition.

Basic Information

Product Name	Brd2
CAS No.	1597439-91-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	BRD2 Inhibitor; Bromodomain-containing protein 2 inhibitor; BRD2 antagonist; (S)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate; 1597439-91-2; BRD2i; BRD2 small molecule inhibitor
EINECS	Contact for details

Quality Control

Every batch of our Brd2 (1597439-91-2) is manufactured under strict quality management systems and undergoes comprehensive analytical characterization to ensure identity, purity, and batch-to-batch consistency. We provide full supporting documentation, including a detailed Certificate of Analysis (COA) with data from HPLC, NMR, and MS. Our quality commitment aligns with standards expected for preclinical research materials.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert atmosphere for long-term stability. Allow the product to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. Store away from strong acids and bases.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.