Description

3-Fluoro-5-Iodopyridin-4-Amine is a high-value halogenated pyridine derivative, a crucial building block in modern synthetic chemistry. Its unique structure, featuring both fluorine and iodine substituents on the pyridine core, makes it an indispensable intermediate for constructing complex molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, leveraging the reactivity of its halogen atoms for structure-activity relationship (SAR) studies.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organometallic chemistry.
• Material Science: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials due to its aromatic and halogenated nature.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to form biaryl and other conjugated systems.
• Chemical Biology & Proteomics: Utilized as a building block for designing molecular probes, tags, and linkers for studying biological systems.

Basic Information

Product Name	3-Fluoro-5-Iodopyridin-4-Amine
CAS No.	1597421-56-1
Molecular Formula	C5H4FIN2
Molecular Weight	237.99 g/mol
Synonyms	4-Amino-3-fluoro-5-iodopyridine; 5-Iodo-3-fluoropyridin-4-amine; 3-Fluoro-5-iodo-4-pyridinamine; 4-Pyridinamine, 3-fluoro-5-iodo-; 3-Fluoro-5-iodopyridin-4-ylamine
EINECS	Contact for details

Quality Control

Every batch of 3-Fluoro-5-Iodopyridin-4-Amine is manufactured under strict quality management protocols. We employ advanced analytical techniques, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.