Description

Isrib (trans-Isomer) is a potent and selective small molecule inhibitor of the integrated stress response (ISR) pathway. This compound is of significant interest for its ability to reverse cognitive deficits and restore memory function in preclinical models, making it a critical research tool for studying neurological disorders and cellular stress mechanisms. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies focused on neurodegeneration, aging, and protein misfolding diseases.

Application

• Neuroscience Research: Investigation of memory formation, synaptic plasticity, and cognitive function in models of Alzheimer's disease, traumatic brain injury, and other neurodegenerative conditions.
• Cellular Stress Studies: Elucidation of the integrated stress response (ISR) pathway, its role in cell survival, and its connection to various disease states.
• Drug Discovery & Development: Serving as a lead compound or pharmacological tool for validating the ISR as a therapeutic target for cognitive disorders and other stress-related pathologies.
• Academic & Preclinical Research: Fundamental research into the mechanisms of learning, memory, and cellular adaptation to environmental stressors.
• Biomarker Development: Assisting in the identification and validation of biomarkers associated with ISR activation in disease models.

Basic Information

Product Name	Isrib (trans-Isomer)
CAS No.	1597403-47-8
Molecular Formula	C₂₄H₂₄F₂N₄O₃
Molecular Weight	454.47 g/mol
Synonyms	ISRIB (trans-Isomer); ISRIB, trans-; trans-ISRIB; Integrated Stress Response Inhibitor (trans-); 2-[(1R,2R,3S,5R)-5-(4-Fluorophenyl)-3-(3-fluorophenyl)-2-hydroxy-8-azabicyclo[3.2.1]octan-8-yl]-2-oxo-N-(pyridin-4-ylmethyl)acetamide; GSK2606414 Inhibitor; EIF2B Activator; Cognitive Enhancer Compound
EINECS	Contact for details

Quality Control

Our Isrib (trans-Isomer) is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research-grade chemicals, ensuring reliable and reproducible results for your critical studies.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. Due to its hygroscopic (moisture-sensitive) nature, the container should be sealed under an inert atmosphere after each use to maintain stability and prevent degradation. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm
Isomeric Purity (trans-)	≥99.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.