Description

(3S,4R)-1-(4-Fluorophenyl)-3-((S)-3-(4-Fluorophenyl)-3-Hydroxypropyl)-4-(4-Hydroxyphenyl)Azetidin-2-One is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. Its complex stereochemistry and functional groups make it a critical building block in the synthesis of novel therapeutic agents. This compound is primarily required by pharmaceutical R&D departments and fine chemical manufacturers engaged in developing next-generation medications.

Application

• Key Intermediate in Drug Synthesis: Serves as a crucial chiral precursor in the multi-step synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting metabolic and central nervous system disorders.
• Pharmaceutical Research & Development: Used extensively in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs) with improved efficacy and safety profiles.
• Process Chemistry & Scale-Up: Employed in optimizing synthetic routes from laboratory scale to pilot plant and commercial manufacturing, focusing on yield, purity, and stereochemical integrity.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis, ensuring batch-to-batch consistency.
• Building Block for β-Lactam Derivatives: Its azetidin-2-one (β-lactam) core structure is leveraged to create novel analogs with potential biological activity beyond traditional antibiotic applications.

Basic Information

Item	Details
Product Name	(3S,4R)-1-(4-Fluorophenyl)-3-((S)-3-(4-Fluorophenyl)-3-Hydroxypropyl)-4-(4-Hydroxyphenyl)Azetidin-2-One
CAS No.	1593543-00-0
Molecular Formula	C24H21F2NO3
Molecular Weight	409.43 g/mol
Synonyms	1-(4-Fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one; (3S,4R)-Ezetimibe Intermediate; Ezetimibe Related Compound; (3S,4R)-1-(p-Fluorophenyl)-3-[(S)-3-(p-fluorophenyl)-3-hydroxypropyl]-4-(p-hydroxyphenyl)azetidin-2-one; (3S,4R)-Azetidin-2-one derivative; Stereoisomer of Ezetimibe precursor; Fluorinated azetidinone intermediate; Chiral β-lactam intermediate.
EINECS	Contact for details

Quality Control

Our production of (3S,4R)-1-(4-Fluorophenyl)-3-((S)-3-(4-Fluorophenyl)-3-Hydroxypropyl)-4-(4-Hydroxyphenyl)Azetidin-2-One adheres to stringent quality systems suitable for pharmaceutical intermediate manufacturing. Each batch is characterized and tested to ensure high chiral purity and chemical identity, with a focus on controlling stereoisomeric and related substance impurities. Comprehensive analytical documentation, including a detailed Certificate of Analysis (COA) with chromatographic data (HPLC, Chiral HPLC), is provided to support your regulatory and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere when appropriate to ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (3S,4R isomer)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.