Description

5-Fluoro-1-Benzofuran-2-Sulfonyl Chloride is a high-purity, reactive sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in enabling the efficient introduction of the sulfonamide functional group, a key pharmacophore in modern drug discovery. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of sulfonamide-based drug candidates, including kinase inhibitors and enzyme modulators.
• Agrochemical Synthesis: Used in the development of new herbicides and fungicides, leveraging the benzofuran scaffold for bioactivity.
• Material Science Research: Employed in the creation of novel polymers and functional materials requiring sulfonated aromatic structures.
• Chemical Biology Probes: Acts as a reactive handle for labeling proteins or modifying biomolecules in probe development.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of complex, target-specific molecules for client projects.

Basic Information

Product Name	5-Fluoro-1-Benzofuran-2-Sulfonyl Chloride
CAS No.	1592452-13-5
Molecular Formula	C8H4ClFO3S
Molecular Weight	234.63 g/mol
Synonyms	5-Fluorobenzofuran-2-sulfonyl chloride; 1-Benzofuran-2-sulfonyl chloride, 5-fluoro-; 5-Fluoro-2-benzofuransulfonyl chloride; 5-Fluorobenzo[b]furan-2-sulfonyl chloride; 2-Benzofuransulfonyl chloride, 5-fluoro-; 5-Fluoro-benzo[b]furan-2-sulfonyl chloride; 5-Fluoro-1-benzofuran-2-sulfonchlorid
EINECS	Contact for details

Quality Control

Our 5-Fluoro-1-Benzofuran-2-Sulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with exacting standards for research and industrial use. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.