Description

Tankyrase-In-2 CAS NO 1588870-36-3 is a potent and selective small-molecule inhibitor of the tankyrase enzymes (TNKS1 and TNKS2), which are key regulators of the Wnt/β-catenin signaling pathway. This compound is a critical research tool for investigating cellular processes related to cancer, fibrosis, and stem cell biology. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in oncology and regenerative medicine studies.

Application

• Biomedical Research: A key chemical probe for fundamental research into the Wnt signaling pathway, its role in tumorigenesis, and cellular homeostasis.
• Oncology Drug Discovery: Used in target validation, high-throughput screening, and as a lead compound for developing novel anti-cancer therapeutics targeting tankyrase.
• Stem Cell & Regenerative Medicine: Employed to study and modulate Wnt signaling in embryonic stem cells, induced pluripotent stem cells (iPSCs), and tissue regeneration models.
• Fibrosis Research: Investigated for its potential to inhibit pathological fibrotic processes in organs such as the liver, lung, and kidney by modulating tankyrase activity.
• Chemical Biology: Serves as a precise tool to dissect the specific functions of tankyrase 1 versus tankyrase 2 in various cellular contexts.
• Preclinical Development: Supports pharmacokinetic (PK), pharmacodynamic (PD), and efficacy studies in animal models of cancer and other Wnt-related diseases.

Basic Information

Product Name	Tankyrase-In-2
CAS No.	1588870-36-3
Molecular Formula	C₂₀H₁₅N₅O₂
Molecular Weight	357.37 g/mol
Synonyms	Tankyrase-IN-2; TNKS-IN-2; 2-[[4-(4-Methyl-2-thiazolyl)-1-piperazinyl]carbonyl]-5H-pyrido[4,3-b]indole; 5H-Pyrido[4,3-b]indole-2-carboxylic acid, 4-(4-methyl-2-thiazolyl)-1-piperazinyl ester; XAV939 analog; Tankyrase 1/2 Inhibitor II; Tankyrase inhibitor (XAV939 related).
EINECS	Contact for details

Quality Control

Our Tankyrase-In-2 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability, consistency, and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This compound is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.