Description

(2R,3S,11Bs)-Dihydrotetrabenazine-D6 is a high-purity, deuterium-labeled isotopologue of dihydrotetrabenazine, a key compound in neurological research. This stable isotope-labeled standard is essential for ensuring accuracy and reliability in quantitative analytical methods, particularly liquid chromatography-mass spectrometry (LC-MS). It is primarily used by pharmaceutical researchers, analytical laboratories, and contract research organizations (CROs) developing and validating assays for vesicular monoamine transporter 2 (VMAT2) ligands and related neuropharmacological studies.

Application

• Internal Standard for LC-MS/MS: Serves as a critical quantitative reference standard in bioanalytical method development and validation for pharmacokinetic and metabolomic studies.
• Neuropharmacology Research: Used in investigative studies targeting the Vesicular Monoamine Transporter 2 (VMAT2) to understand neurotransmitter storage and release mechanisms.
• Drug Metabolism and Pharmacokinetics (DMPK): Enables precise tracking and quantification of the parent compound and its metabolites in biological matrices.
• Quality Control in Reference Standard Production: Acts as a calibrant or system suitability check in the manufacturing and certification of non-labeled active pharmaceutical ingredients (APIs).
• Clinical Research Assays: Supports the development of diagnostic or monitoring assays for neurological conditions where VMAT2 ligands are relevant.

Basic Information

Product Name	(2R,3S,11Bs)-Dihydrotetrabenazine-D6
CAS No.	1583277-33-1
Molecular Formula	C19H21D6NO3
Molecular Weight	323.45 g/mol (approx.)
Synonyms	(+)-α-Dihydrotetrabenazine-D6; (2R,3S,11bS)-1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-ol-D6; Dihydrotetrabenazine-d6; DHTBZ-D6; Deuterated Dihydrotetrabenazine; VMAT2 Inhibitor Deuterated Standard; Tetrabenazine Metabolite Deuterated Standard
EINECS	Contact for details

Quality Control

Every batch of (2R,3S,11Bs)-Dihydrotetrabenazine-D6 is manufactured and analyzed under strict quality systems. We provide comprehensive Certificates of Analysis (COA) detailing purity, isotopic enrichment, and identity confirmation via advanced spectroscopic and chromatographic methods. Our quality commitment ensures the material meets the stringent requirements for use as a certified reference standard in regulated research environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant and inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥98.0%
Isotopic Enrichment (MS)	≥98.0 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.