Description

Rip2 Kinase Inhibitor 2 CAS NO 1581270-11-2 is a potent and selective small-molecule inhibitor targeting the Receptor-interacting protein 2 (RIP2) kinase, a key regulator in the NOD1/NOD2 signaling pathways involved in inflammatory and immune responses. This compound is essential for researchers and developers in the pharmaceutical and biotechnology sectors seeking to modulate innate immunity and explore novel therapeutic avenues for autoimmune diseases, inflammatory disorders, and certain cancers. Its high specificity makes it a critical tool for target validation, mechanism-of-action studies, and preclinical drug discovery programs.

Application

• Biomedical Research: Fundamental tool for studying the role of RIP2 kinase in NOD1/NOD2-mediated inflammatory signaling pathways.
• Drug Discovery & Development: Used as a lead compound or pharmacological probe in high-throughput screening and hit-to-lead optimization for inflammatory disease targets.
• Preclinical Studies: Employed in in vitro and in vivo models to investigate therapeutic potential for conditions like Crohn's disease, ulcerative colitis, and psoriasis.
• Immunology Research: Facilitates the exploration of innate immune system regulation and the crosstalk between inflammation and apoptosis.
• Chemical Biology: Serves as a key reagent for developing assays, understanding structure-activity relationships (SAR), and identifying novel binding sites.
• Academic & Institutional Research: Critical for university and research institute labs focused on kinase biology, signal transduction, and immunopharmacology.

Basic Information

Product Name	Rip2 Kinase Inhibitor 2
CAS No.	1581270-11-2
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.42 g/mol
Synonyms	RIP2 Inhibitor 2; RIPK2 Inhibitor 2; 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 6-(4-fluorophenyl)-N,1-dimethyl-3-(4-methyl-1-piperazinyl)-; GSK583; Compound 2; Receptor-interacting serine/threonine-protein kinase 2 inhibitor; NOD signaling inhibitor
EINECS	Contact for details

Quality Control

Our Rip2 Kinase Inhibitor 2 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by comprehensive analytical data, including HPLC chromatograms and NMR spectra. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. Due to its hygroscopic nature, the product should be handled under inert atmosphere or in a desiccator when weighing to ensure long-term stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.