Description

Casein Kinase 1δ-In-6 is a potent and selective small molecule inhibitor of the CK1δ (Casein Kinase 1 Delta) enzyme, a key regulator in cellular signaling pathways. This compound is crucial for researchers investigating the role of CK1δ in disease mechanisms, particularly in oncology and neurodegenerative disorders. It is an essential tool for pharmaceutical R&D, academic research, and biotechnology laboratories focused on kinase-targeted drug discovery and signal transduction studies.

Application

• Biochemical Research: Used as a selective probe to study the physiological and pathological functions of CK1δ in cellular models.
• Drug Discovery & Development: Serves as a lead compound or reference standard in high-throughput screening and structure-activity relationship (SAR) studies for CK1δ-targeted therapeutics.
• Oncology Research: Investigated for its potential effects on cancer cell proliferation, apoptosis, and circadian rhythm disruption in various cancer types.
• Neuroscience Research: Applied in studies exploring CK1δ's role in tau phosphorylation, amyloid-beta production, and other pathways relevant to Alzheimer's disease and other tauopathies.
• Cell Signaling Pathway Analysis: A key reagent for dissecting the Wnt/β-catenin, Sonic Hedgehog, and p53 signaling pathways where CK1δ is involved.
• In Vitro & In Vivo Studies: Utilized in both cell-based assays and animal models to validate CK1δ as a therapeutic target and assess inhibitor efficacy.

Basic Information

Product Name	Casein Kinase 1δ-In-6
CAS No.	1579991-01-7
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.41 g/mol
Synonyms	CK1δ-In-6; Casein Kinase 1 Delta Inhibitor 6; 1-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-3-(4-fluorophenyl)urea; PF-670462; PF670462; PF 670462; CK1δ Inhibitor VI; (3-Cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-(4-fluorophenyl)urea
EINECS	Contact for details

Quality Control

Our Casein Kinase 1δ-In-6 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and Mass Spectrometry, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent performance.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This compound is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (Mass Spectrometry)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.