Description

Ethyl 6-(Difluoromethyl)Nicotinate is a high-value, fluorinated nicotinate derivative serving as a critical synthetic intermediate in advanced organic chemistry. Its core value lies in the strategic incorporation of the difluoromethyl group, which can significantly alter the physicochemical and metabolic properties of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to construct novel active ingredients with enhanced efficacy and stability.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting kinase inhibitors or central nervous system (CNS) agents.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, where the difluoromethyl moiety can improve bioavailability and environmental persistence.
• Material Science Precursor: Serves as a monomer or functionalization agent in the synthesis of specialty polymers and liquid crystals with tailored electronic or surface properties.
• Chemical Biology Probe Synthesis: Employed to create fluorinated analogs of natural products or biochemical probes for studying enzyme mechanisms and metabolic pathways.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	Ethyl 6-(Difluoromethyl)Nicotinate
CAS No.	1574401-80-1
Molecular Formula	C9H9F2NO2
Molecular Weight	201.17 g/mol
Synonyms	Ethyl 6-(difluoromethyl)pyridine-3-carboxylate; 3-Pyridinecarboxylic acid, 6-(difluoromethyl)-, ethyl ester; 6-(Difluoromethyl)nicotinic acid ethyl ester; Ethyl 6-difluoromethylnicotinate; Nicotinic acid, 6-(difluoromethyl)-, ethyl ester
EINECS	Contact for details

Quality Control

Every batch of Ethyl 6-(Difluoromethyl)Nicotinate is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the exacting standards required for research and scale-up activities. A detailed Certificate of Analysis (COA) confirming identity, purity, and impurity profile by HPLC, NMR, and MS is supplied with each shipment to guarantee reproducible results and supply chain integrity for your critical projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.