Description

1-(Difluoromethyl)-4-Ethynylbenzene is a high-purity, multi-functional aromatic building block featuring both a difluoromethyl and an ethynyl group. This unique bifunctional structure makes it a valuable intermediate for the synthesis of advanced materials and active pharmaceutical ingredients (APIs), particularly in medicinal chemistry where fluorine substitution is critical. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel drug candidates, especially in kinase inhibitors and other targeted therapies where the difluoromethyl group modulates pharmacokinetic properties.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, leveraging fluorine's ability to enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the synthesis of specialty polymers, liquid crystals, and organic electronic materials via its reactive ethynyl group.
• Fluorine Chemistry Research: An essential reagent for studying structure-activity relationships (SAR) and for introducing the difluoromethyl motif into complex molecules.
• Click Chemistry Applications: The terminal alkyne functionality enables participation in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions for bioconjugation and polymer functionalization.

Basic Information

Product Name	1-(Difluoromethyl)-4-Ethynylbenzene
CAS No.	1567114-39-9
Molecular Formula	C9H6F2
Molecular Weight	152.14 g/mol
Synonyms	4-Ethynyl-α,α-difluorotoluene; 4-Ethynylbenzylidene Difluoride; 1-Ethynyl-4-(difluoromethyl)benzene; p-(Difluoromethyl)phenylacetylene; (4-(Difluoromethyl)phenyl)ethyne; Difluoromethyl Ethynyl Benzene; DFMPA
EINECS	Contact for details

Quality Control

Our 1-(Difluoromethyl)-4-Ethynylbenzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high chemical purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support cGMP and ISO 9001 standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and light-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use. Keep away from strong oxidizers and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.