Description

5,6-Trans Travoprost is a key synthetic prostaglandin analog and a critical isomer in the development of ophthalmic pharmaceutical agents. This compound matters for its role as a high-purity intermediate in the synthesis of advanced glaucoma treatments, where precise stereochemistry is essential for biological activity and regulatory approval. Pharmaceutical R&D laboratories and active pharmaceutical ingredient (API) manufacturers need this specific isomer to ensure the efficacy, safety, and consistency of their final drug products.

Application

• Pharmaceutical Intermediate: Primary use as a high-value building block in the synthesis of Travoprost API and related prostaglandin analogs.
• Ophthalmic Drug Development: Critical for research and production of next-generation intraocular pressure-lowering medications for glaucoma and ocular hypertension.
• Process Chemistry & Scale-Up: Serves as a reference standard and starting material for process optimization and analytical method development in API manufacturing.
• Regulatory & Quality Control: Used as an analytical reference standard (RS) for impurity profiling, method validation, and ensuring batch-to-batch consistency in compliance with ICH guidelines.
• Academic & Contract Research: Enables biochemical and pharmacological studies on prostaglandin receptor activity and structure-activity relationships (SAR).

Basic Information

Product Name	5,6-Trans Travoprost
CAS No.	1563176-59-9
Molecular Formula	C₂₆H₃₅F₃O₆
Molecular Weight	500.55 g/mol
Synonyms	Travoprost Impurity F; Travoprost EP Impurity F; Travoprost Related Compound F; (5Z,13E)-(9S,11R,15R)-9,11,15-Trihydroxy-17-phenyl-18,19,20-trinorprosta-5,13-dien-1-oic Acid Isopropyl Ester; 5,6-trans-Isopropyl (Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3R)-3-hydroxy-4,4,4-trifluoro-1-buten-1-yl]cyclopentyl]-5-heptenoate; Prostaglandin F2α analog isomer; AL-6221 isomer
EINECS	Contact for details

Quality Control

Our 5,6-Trans Travoprost is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to confirm isomeric identity, ensuring it meets the stringent requirements for pharmaceutical development. Certificates of Analysis (COA) with detailed chromatographic data are provided and can be tailored to support regulatory filings (e.g., ICH Q3A, Q3B).

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the certificate of analysis. For long-term storage, consider storing under inert atmosphere at -20°C to maximize stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual unknown impurity ≤ 0.5% Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.