Description

Banoxantrone (D12) is a deuterated isotopologue of the anthracenedione derivative, Banoxantrone, where twelve hydrogen atoms are replaced with deuterium. This compound serves as a critical stable isotope-labeled internal standard for the precise quantification and pharmacokinetic analysis of its parent drug in complex biological matrices. It is an essential tool for researchers and quality control laboratories in the pharmaceutical and biotechnology sectors, particularly those focused on oncology drug development and bioanalytical method validation.

Application

• Bioanalytical Reference Standard: Primary use as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for accurate quantification of Banoxantrone.
• Pharmacokinetic and Metabolism Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Drug Development and Validation: Critical for developing and validating robust, regulatory-compliant bioanalytical assays for new drug applications (NDA).
• Clinical Trial Support: Used in bioanalysis for patient samples during clinical trials to ensure data accuracy and reliability.
• Quality Control in Manufacturing: Supports impurity profiling and batch consistency testing for active pharmaceutical ingredient (API) manufacturers.

Basic Information

Product Name	Banoxantrone (D12)
CAS No.	1562067-05-3
Molecular Formula	C₂₃H₁₆D₁₂N₄O₆
Molecular Weight	~476.53 g/mol
Synonyms	AQ4N-d12; Banoxantrone-d12; 1,4-Bis[[2-[(dimethylamino-d6)ethyl]amino]-5,8-dihydroxyanthracene-9,10-dione; Deuterated Banoxantrone; D12-Banoxantrone; Stable Isotope-Labeled Banoxantrone; Anthracenedione-d12 derivative
EINECS	Contact for details

Quality Control

Our Banoxantrone (D12) is produced and handled under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for chemical purity and isotopic enrichment, NMR for structural confirmation, and mass spectrometry for identity verification. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade standards. Specifications are designed to meet the rigorous demands of bioanalytical and pharmaceutical development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. Keep the container in a dry, cool, and well-ventilated place. For long-term storage, consider storing under inert atmosphere.

Specification

Item	Specification
Appearance	Solid (Color to be specified)
Identification (HPLC-MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥95% (Area %)
Isotopic Purity (D-enrichment)	≥98 atom % D
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.