Description

5-Fluoro-6-Trifluoromethyl-Nicotinic Acid is a high-value, multi-fluorinated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both fluorine and a trifluoromethyl group on the nicotinic acid scaffold, makes it indispensable for modulating the physicochemical properties of target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients with enhanced metabolic stability, bioavailability, and lipophilicity.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in oncology, CNS, and antiviral therapeutic areas.
• Agrochemical Synthesis: Used in the design and production of advanced herbicides, fungicides, and insecticides where the fluorine motifs improve biological activity and environmental profile.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands and catalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of fluorinated organic semiconductors, liquid crystals, and other functional materials.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up services for specialized chemical entities.

Basic Information

Product Name	5-Fluoro-6-Trifluoromethyl-Nicotinic Acid
CAS No.	1554123-46-4
Molecular Formula	C7H3F4NO2
Molecular Weight	209.10 g/mol
Synonyms	5-Fluoro-6-(trifluoromethyl)pyridine-3-carboxylic acid; 3-Pyridinecarboxylic acid, 5-fluoro-6-(trifluoromethyl)-; 5-Fluoro-6-trifluoromethylnicotinic acid; 6-Trifluoromethyl-5-fluoronicotinic acid; 1554123-46-4; 5-Fluoro-6-(trifluoromethyl)nicotinic acid
EINECS	Contact for details

Quality Control

Every batch of 5-Fluoro-6-Trifluoromethyl-Nicotinic Acid is manufactured under strict quality management systems. We provide comprehensive analytical documentation to ensure traceability and compliance with your project requirements. Our standard quality commitment includes rigorous testing for identity, purity, and impurity profiles using advanced techniques like HPLC, NMR, and MS. Certificates of Analysis (COA) are available upon request, detailing the specific results for your shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its acidic nature, keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.