Description

Btk Inhibitor 1 (R Enantiomer Hydrochloride) is a potent and selective small molecule inhibitor of Bruton's tyrosine kinase (Btk). This compound is of significant value for research into B-cell signaling pathways and the development of targeted therapies for autoimmune diseases and B-cell malignancies. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on immunology and oncology.

Application

• Biochemical Research: Used as a critical tool compound for studying Btk-mediated signaling cascades in immune cell function.
• Drug Discovery & Development: Serves as a reference standard and a lead compound in the development of novel Btk inhibitors for therapeutic applications.
• Cellular Assays: Employed in in vitro studies to investigate the effects of Btk inhibition on B-cell activation, proliferation, and survival.
• Target Validation: Utilized to confirm the role of Btk in specific disease models, aiding in the identification of new therapeutic targets.
• Preclinical Studies: Supports pharmacokinetic and pharmacodynamic evaluations in animal models of autoimmune and inflammatory conditions.

Basic Information

Product Name	Btk Inhibitor 1 (R Enantiomer Hydrochloride)
CAS No.	1553977-42-6
Molecular Formula	C21H21ClN6O2 • HCl
Molecular Weight	485.35 g/mol
Synonyms	(R)-Btk Inhibitor 1 hydrochloride; (R)-5-Fluoro-3-(4-((5-fluoro-2-methoxypyridin-3-yl)amino)-6-(4-methyl-1H-imidazol-1-yl)pyrimidin-2-yl)benzonitrile hydrochloride; Btk Inhibitor 1, (R)-enantiomer, hydrochloride; GNE-2743 (R enantiomer hydrochloride); 5-Fluoro-3-[4-[[(5-fluoro-2-methoxypyridin-3-yl)amino]-6-(4-methylimidazol-1-yl)pyrimidin-2-yl]benzonitrile (R enantiomer) hydrochloride
EINECS	Contact for details

Quality Control

Our Btk Inhibitor 1 (R Enantiomer Hydrochloride) is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and potency. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (Mass Spectrometry)	Conforms
Purity (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% (R enantiomer)
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.