Description

Autotaxin Modulator 1 is a potent and selective small-molecule inhibitor of the autotaxin enzyme, a key regulator of lysophosphatidic acid (LPA) production. This compound matters for researchers and developers targeting the LPA signaling pathway, which is implicated in fibrosis, inflammation, cancer, and neuropathic pain. It is needed by pharmaceutical R&D teams, academic institutions, and contract research organizations (CROs) focused on developing novel therapeutics for these challenging conditions.

Application

• Pharmaceutical Research & Development: A critical tool for in vitro and in vivo studies to validate autotaxin as a therapeutic target.
• Fibrosis Drug Discovery: Used to investigate and develop potential treatments for idiopathic pulmonary fibrosis (IPF), liver fibrosis, and renal fibrosis.
• Oncology Research: Employed in studies exploring the role of autotaxin and LPA in cancer cell proliferation, migration, and metastasis.
• Inflammation and Pain Studies: Applied in preclinical models to assess efficacy in neuropathic pain, rheumatoid arthritis, and other inflammatory diseases.
• Biochemical Assay Development: Serves as a reference standard or positive control in high-throughput screening (HTS) campaigns and enzymatic assays.
• Mechanism of Action (MoA) Studies: Utilized to elucidate downstream signaling pathways and biological effects of autotaxin inhibition.

Basic Information

Product Name	Autotaxin Modulator 1
CAS No.	1548743-69-6
Molecular Formula	C23H21N5O3S
Molecular Weight	447.51 g/mol
Synonyms	ATX Inhibitor 1; Autotaxin Inhibitor; 4-[[4-[[[3-(Methylsulfonyl)phenyl]methyl]amino]-6-(3-pyridinyl)-2-pyrimidinyl]amino]benzonitrile; PF-8380; PF 8380; PF8380; (4-((4-((3-(Methylsulfonyl)benzyl)amino)-6-(pyridin-3-yl)pyrimidin-2-yl)amino)benzonitrile)
EINECS	Contact for details

Quality Control

Our Autotaxin Modulator 1 is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay results, and impurity profiles is provided with each shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.