Description

2,6-Difluoro-3-Methylbenzenesulfonylchloride is a high-purity, specialized sulfonyl chloride derivative used as a critical building block in advanced organic synthesis. Its value lies in its role as a versatile sulfonylation reagent, enabling the introduction of the sulfonyl functional group into complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of sulfonamide-based active pharmaceutical ingredients (APIs), including potential kinase inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that incorporate sulfonylurea or sulfonamide moieties.
• Material Science Research: Employed in the development of specialty polymers, dyes, and functional materials where the sulfonyl group modifies physical or chemical properties.
• Chemical Biology & Proteomics: Serves as a reagent for labeling and modifying biomolecules, such as proteins and peptides, in probe development and activity-based protein profiling (ABPP).
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	2,6-Difluoro-3-Methylbenzenesulfonylchloride
CAS No.	1548143-20-9
Molecular Formula	C7H5ClF2O2S
Molecular Weight	226.63 g/mol
Synonyms	2,6-Difluoro-3-methylbenzenesulfonyl chloride; 3-Methyl-2,6-difluorobenzenesulfonyl chloride; Benzenesulfonyl chloride, 2,6-difluoro-3-methyl-; 2,6-Difluoro-3-methyl-1-benzenesulfonyl chloride; 2,6-Difluoro-m-toluenesulfonyl chloride; 1548143-20-9 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Our 2,6-Difluoro-3-Methylbenzenesulfonylchloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.