Description

[2H8]-Carbamazepine CAS NO 1538624-35-9 is a stable isotope-labeled analog of the widely used anticonvulsant and mood-stabilizing drug, carbamazepine, where eight hydrogen atoms are replaced by deuterium. This high-purity labeled compound is an essential internal standard for quantitative mass spectrometry, enabling precise pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in bioanalytical method development and drug metabolism and pharmacokinetics (DMPK) research.

Application

• Bioanalytical Internal Standard: Serves as a critical reference compound in LC-MS/MS assays for the accurate quantification of carbamazepine and its metabolites in biological matrices like plasma, serum, and urine.
• Drug Metabolism Studies: Used to trace and elucidate metabolic pathways, identify metabolites, and study the pharmacokinetic profile of carbamazepine in preclinical and clinical research.
• Therapeutic Drug Monitoring (TDM): Enables the development and validation of highly specific and sensitive assays for monitoring carbamazepine levels in patient samples to optimize dosing and ensure therapeutic efficacy.
• Forensic and Toxicology Analysis: Provides a reliable standard for the confirmatory analysis of carbamazepine in forensic toxicology cases, ensuring high accuracy and minimizing matrix effects.
• Pharmaceutical Quality Control: Employed in the analysis of drug substances and finished products to ensure purity, potency, and consistency in manufacturing.
• Isotope Dilution Mass Spectrometry (IDMS): Acts as the ideal spike-in standard for absolute quantification methods, correcting for sample loss and ionization variability during MS analysis.

Basic Information

Item	Detail
Product Name	[2H8]-Carbamazepine
CAS No.	1538624-35-9
Molecular Formula	C15H4D8N2O
Molecular Weight	244.33 g/mol
Synonyms	Carbamazepine-d8; Deuterated Carbamazepine (d8); 5H-Dibenzo[b,f]azepine-5-carboxamide-d8; 5-Carbamoyl-5H-dibenzo[b,f]azepine-d8; CBZ-d8; NSC 169864-d8; Tegretol-d8 (labeled analog); Isotopic Internal Standard for Carbamazepine
EINECS	Contact for details

Quality Control

Every batch of [2H8]-Carbamazepine is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive testing performed using advanced techniques including NMR, HPLC, and mass spectrometry. A Certificate of Analysis (COA) detailing batch-specific results for identity, purity (HPLC), isotopic enrichment, and residual solvents is provided with each shipment to ensure traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term stability, consider storage at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (by HPLC)	≥ 99.0%
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.