Description

Piperazine Erastin is a potent and selective ferroptosis inducer, a compound of significant interest in biochemical and pharmaceutical research. Its mechanism of action, which involves inhibiting system xc- and depleting intracellular glutathione, makes it a critical tool for studying regulated cell death pathways. This high-purity compound is essential for researchers and developers in oncology, neurobiology, and drug discovery programs focused on novel therapeutic targets.

Application

• Biomedical Research: A key reagent for inducing and studying ferroptosis in various in vitro and in vivo cancer models.
• Drug Discovery & Screening: Used as a reference compound and positive control in high-throughput assays to identify novel ferroptosis inhibitors or modulators.
• Mechanistic Studies: Investigating the role of iron metabolism, lipid peroxidation, and antioxidant defense systems in cellular physiology and disease pathology.
• Oncology Research: Exploring therapeutic strategies to selectively trigger ferroptosis in drug-resistant or apoptosis-resistant cancer cell lines.
• Neurodegenerative Disease Research: Studying the potential links between ferroptosis and conditions such as Alzheimer's, Parkinson's, and stroke.
• Academic & Institutional Labs: Fundamental research tool for universities and research institutes in cell biology and pharmacology departments.

Basic Information

Product Name	Piperazine Erastin
CAS No.	1538593-71-3
Molecular Formula	C30H31N7O3
Molecular Weight	537.61 g/mol
Synonyms	Erastin, Piperazine Erastin; (S)-1-[(4-{[3,5-Bis(trifluoromethyl)phenyl]carbamoyl}piperazin-1-yl)carbonyl]-2-(4-hydroxyphenyl)ethyl 4-Benzylpiperazine-1-carboxylate; NSC 146587; Ferroptosis Inducer I; System xc- Inhibitor
EINECS	Contact for details

Quality Control

Our Piperazine Erastin is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.