Description

1-Bromo-2-(Chloromethyl)-3-Fluoro-4-Methoxybenzene is a high-purity, multi-functional halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique substitution pattern makes it a critical intermediate for constructing complex molecular architectures. This compound is primarily needed by R&D and production chemists in the pharmaceutical, agrochemical, and specialty materials industries for developing new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides, where the fluorine and halogenated benzyl groups enhance biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized phosphine or nitrogen-based ligands used in asymmetric catalysis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of monomers for specialty polymers, liquid crystals, or organic electronic materials due to its aromatic core and reactive sites.
• Chemical Biology Probes: Useful for synthesizing tagged molecules or photoaffinity labels for proteomics and molecular biology research applications.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global fine chemical market.

Basic Information

Item	Detail
Product Name	1-Bromo-2-(Chloromethyl)-3-Fluoro-4-Methoxybenzene
CAS No.	1516298-29-5
Molecular Formula	C8H7BrClFO
Molecular Weight	253.50 g/mol
Synonyms	2-Bromo-1-(Chloromethyl)-6-Fluoro-3-Methoxybenzene; 3-Fluoro-4-Methoxy-2-(Chloromethyl)-1-Bromobenzene; 1-Bromo-2-(chloromethyl)-3-fluoro-4-methoxy-benzene; 1516298-29-5; Benzene, 1-bromo-2-(chloromethyl)-3-fluoro-4-methoxy-; 4-Methoxy-3-fluoro-2-(chloromethyl)-1-bromobenzene
EINECS	Contact for details

Quality Control

Our 1-Bromo-2-(Chloromethyl)-3-Fluoro-4-Methoxybenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive and easily oxidized; for long-term storage, consider maintaining under an inert atmosphere (e.g., nitrogen or argon) to preserve stability and purity. Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (HPLC/GC-MS)	Conforms
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 96.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.