Description

(2-Fluoro-4-Methylphenyl)Methanesulfonyl Chloride is a high-value sulfonyl chloride derivative, a key building block in advanced organic synthesis. Its primary value lies in its role as a versatile electrophilic reagent for introducing the (2-fluoro-4-methylphenyl)methanesulfonyl moiety, enabling the construction of complex molecules with tailored properties. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for sulfonamide-based drugs and kinase inhibitors.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the fluorine and sulfonyl groups confer specific biological activity.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers and advanced materials with specific surface properties.
• Chemical Biology & Proteomics: Employed as a reactive handle for labeling, cross-linking, or modifying biomolecules in probe development and biochemical studies.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	(2-Fluoro-4-Methylphenyl)Methanesulfonyl Chloride
CAS No.	1505607-08-8
Molecular Formula	C9H10ClFO2S
Molecular Weight	236.69 g/mol
Synonyms	2-Fluoro-4-methylbenzenemethanesulfonyl chloride; 1-(Chlorosulfonylmethyl)-2-fluoro-4-methylbenzene; (2-Fluoro-p-tolyl)methanesulfonyl chloride; α-Chlorosulfonyl-2-fluoro-4-methyltoluene; 2-Fluoro-4-methylbenzylsulfonyl chloride; 4-Methyl-2-fluorobenzylsulfonyl chloride; 2-Fluoro-4-methylphenylmethylsulfonyl chloride
EINECS	Contact for details

Quality Control

Our (2-Fluoro-4-Methylphenyl)Methanesulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.