Description

Bet Bromodomain Inhibitor CAS NO 1505453-59-7 is a potent and selective small molecule inhibitor targeting the bromodomain and extra-terminal (BET) family of proteins. This compound is a critical research tool for investigating epigenetic regulation and has significant potential in the development of novel therapeutics for oncology, inflammation, and other diseases. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and CROs engaged in drug discovery and molecular biology studies.

Application

• Drug Discovery & Preclinical Research: A key chemical probe for validating BET proteins as therapeutic targets in various disease models.
• Oncology Research: Investigation into the role of BET proteins in cancer cell proliferation, survival, and tumor progression.
• Inflammatory & Autoimmune Disease Studies: Research into modulating gene expression programs driven by BET protein activity.
• Epigenetics & Transcriptional Regulation: Fundamental research tool for studying chromatin remodeling and gene expression control.
• Biochemical Assay Development: Used as a reference standard in high-throughput screening (HTS) and binding assays.
• Chemical Biology: Employed in structure-activity relationship (SAR) studies to design next-generation inhibitors.

Basic Information

Product Name	Bet Bromodomain Inhibitor
CAS No.	1505453-59-7
Molecular Formula	C21H21ClN6O2S
Molecular Weight	480.95 g/mol
Synonyms	BET Inhibitor; Bromosporine; (R)-6-(4-Chlorophenyl)-8-ethoxy-2-(1-hydroxyethyl)-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine; GSK 525762A analog; I-BET151 analog; BRD4 Inhibitor; (+)-JQ1; BET bromodomain antagonist
EINECS	Contact for details

Quality Control

Our Bet Bromodomain Inhibitor is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.